Harnessing the healing power within our cells

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University of Queensland researchers have identified a pathway in cells that can be used to reprogram the body’s immune system to fight chronic inflammatory and infectious diseases.

Dr Kaustav Das Gupta and Professor Matt Sweet of the University of Queensland’s Institute of Molecular Biosciences discovered that a molecule derived from glucose in immune cells It can stop the growth of bacteria and moisturize inflammatory responses. Dr Das Gupta said this finding is a crucial step towards future therapies that train immune cells.

Research published in Proceedings of the National Academy of Sciences (PNAS).

“The effect of this molecule called ribulose-5-phosphate on bacteria is amazing – it can cooperate with other immune factors to stop the growth of pathogenic strains of Escherichia coli,” said Dr Das Gupta.

It also reprograms immune system To stop the destructive inflammation that contributes to life threatening Infectious diseases such as sepsis as well as chronic inflammatory diseases such as respiratory diseases, Chronic liver diseaseAnd Inflammatory bowel diseaserheumatoid arthritis, heart disease, stroke, diabetes, and dementia.”

The research was conducted on a strain of Escherichia coli bacteria that causes nearly 80 percent of urinary tract infections and is a common cause of sepsis.

Preclinical trials were used to confirm the role of this pathway in controlling bacterial infections.

Sweet Professor said human cells They were also used to demonstrate that ribulose-5-phosphate reduces the production of molecules that cause chronic inflammatory diseases.

“Host-directed therapies, which train our immune systems to fight infection, will become increasingly important as more bacteria become resistant to known antibiotics,” said Professor Sweet.

“The bonus is that this strategy also halts destructive inflammation, giving it the ability to fight chronic disease. By boosting the immune pathway that generates ribulose-5-phosphate, we may be able to give the body the strength to fight off chronic disease. Inflammatory and infectious diseases — not one, but two. a major global challenge to human health.”

Many current anti-inflammatory therapies target proteins on the outside of cells, but because this pathway occurs inside cells, the researchers devised a new approach to target the pathway using mRNA technology.

Professor Sweet said the technology showed promise for delivering the enzyme that generates ribulose-5-phosphate into immune cells and has been registered as a provisional patent by UniQuest, the University of Queensland’s marketing company.

The work involved both international and national collaborations, including University of Queensland researchers Professor David Fairley and Professor Mark Schembri as key collaborators.

more information:
Kaustav Das Gupta et al, HDAC7 is an immune metabolism switch that secretes danger signals to engage antimicrobial versus inflammatory responses in macrophages, Proceedings of the National Academy of Sciences (2023). DOI: 10.1073/pnas.2212813120

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the quote: Harnessing the Healing Power Within Our Cells (2023, January 18) Retrieved January 19, 2023 from https://phys.org/news/2023-01-harnessing-power-cells.html

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